During summer, urea should be spread just before, or during rain to reduce possible losses from volatilisation (process where nitrogen is lost to the atmosphere as ammonia gas). Urea should not be mixed for any length of time with other fertilizers as problems of physical quality may result.

Because of the high nitrogen concentration in urea, it is very important to achieve an even spread. Make sure that the application equipment has been correctly calibrated and is properly used. Do not drill on contact with or close to seed, due to the risk of germination damage. Urea dissolves in water for application as a spray or through irrigation systems.

In grain and cotton crops, urea is often applied at the time of the last cultivation before planting. It should be applied into, or be incorporated into the soil. In high rainfall areas and on sandy soils (where nitrogen can be lost through leaching) and where good in-season rainfall is expected, urea can be side or top-dressed during the growing season. Top-dressing is also popular on pasture and forage crops. In sugarcane, urea is side-dressed after planting, and applied to each ratoon crop (see ratooning).

In irrigated crops, urea can be applied dry to the soil, or dissolved and applied through the irrigation water. Urea will dissolve in its own weight in water, but it becomes increasingly difficult to dissolve as the concentration increases. Dissolving urea in water is endothermic, causing the temperature of the solution to fall when urea dissolves.

As a practical guide, when preparing urea solutions for fertigation (injection into irrigation lines), dissolve no more than 30 kg urea per 100 L water.

In foliar sprays, urea concentrations of 0.5 – 2.0% are often used in horticultural crops. As urea sprays may damage crop foliage, specific advice should be sought before use. Low biuret grades of urea should be used if urea sprays are to be applied regularly or to sensitive horticultural crops.

Storage of urea fertilizer

Like most nitrogen products, urea absorbs moisture from the atmosphere. Therefore it should be stored either in closed/sealed bags on pallets, or if stored in bulk, covered with a tarpaulin. As with most solid fertilizers, it should also be stored in a cool, dry, well ventilated area.

Industrial use

Urea has the ability to form 'loose compounds' with many organic compounds. The organic compounds are held in channels formed by interpenetrating helices comprising of hydrogen bonded urea molecules. This behaviour can be used to separate mixtures and has been used in the production of aviation fuel and lubricating oils. As the helices are interconnected all helices in a crystal must have the same 'handedness'. This is determined when the crystal is nucleated and can thus be forced by seeding. This property has been used to separate racemic mixtures.

Urea specification

Mocznik - granulat UREA Mocznik - CO(NH2)2 jest produktem otrzymywanym z amoniaku i dwutlenku węgla w procesie syntezy wg technologii firmy Toyo Koatsu lub Tecnimont i granulowany metodą wieżową. Mocznik występuje w postaci białych granulek. Pakowanie Mocznik nawozowy jest pakowany i znakowany zgodnie z PN-C-87001:1998 worki polietylenowe o pojemności 25 kg kontenery elastyczne typu big-bag o pojemności 500÷1800 kg luzem w wagonach krytych Po uzgodnieniu z odbiorcą i przewoźnikiem dopuszcza się inny rodzaj opakowania zabezpieczający produkt przed zmianą jakości i mający wymiary zgodne z PN-89/O-79021 Transport Mocznik nawozowy należy przewozić krytymi środkami transportowymi. W każdym przypadku środki transportu powinny być czyste i suche. Mocznik nie podlega przepisom RID oraz ADR. Zastosowanie Mocznik nawozowy stosowany jest w rolnictwie do nawożenia upraw. Warunki przechowywania Ze względu na higroskopijność mocznik należy przechowywać w czystych i suchych budynkach magazynowych lub pod wiatami w stosach do wysokości 12 warstw worków. Big-bagi nieprzekraczające masy 500 kg należy układać najwyżej w dwie warstwy. Mocznik luzem przechowywać w pryzmach w zadaszonych magazynach. Nieprzestrzeganie powyższych zasad może spowodować zbrylanie się mocznika. Środki ostrożności mocznik jest nietoksyczny i nie tworzy mieszanin wybuchowych z powietrzem podczas pracy stosuje się standardową odzież roboczą w przypadku podrażnienia, skórę i oczy przemyć dużą ilością wody w razie nadmiernego zapylenia lub operacji mogących spowodować obsypanie należy stosować szczelne gogle ochronne w razie przypadkowego spożycia należy zasięgnąć porady lekarza chronić przed wilgocią i nasłonecznieniem. Mocznik, karbamid (ang. urea) - CO(NH2)2 - organiczny związek chemiczny diamid kwasu węglowego. Tworzy bezbarwne kryształy bez zapachu o temperaturze topnienia ok 133°C. W roku 1773 r. mocznik z moczu uzyskał G. F. Rouelle Związek ten sztucznie otrzymany został po raz pierwszy przez Friedricha Wöhlera w 1828 r. Mocznik był pierwszym związkiem organicznym otrzymanym z całkowicie nieorganicznych substratów w wyniku ogrzewania cyjanianu amonu: NH4NCO › H2N-CO-NH2 czym dowiedziono niesłuszność teorii "siły życiowej", rzekomo niezbędnej do syntezy związków produkowanych przez żywe organizmy. W przemyśle mocznik jest otrzymywany w bezpośredniej reakcji dwutlenku węgla z amoniakiem: CO2 + 2NH3 › CO(NH2)2 + H2O Jest to końcowy produkt przemiany białek i innych związków azotowych w organizmie. Jest wydalany z moczem, a w niewielkich ilościach z potem. Stosowany jest jako surowiec w produkcji tworzyw sztucznych, a także do produkcji leków i kosmetyków. W rolnictwie stosowany jako: nawóz mineralny(zawiera 46% azotu i do 0.9% biuretu), substancja konserwująca, dodatek do pasz dla bydła. Urea is an organic compound with the chemical formula (NH2)2CO. Urea is also known as carbamide, especially in the recommended International Nonproprietary Names (rINN) in use in Europe. For example, the medicinal compound hydroxyurea (old British Approved Name) is now hydroxycarbamide. Other names include carbamide resin, isourea, carbonyl diamide, and carbonyldiamine. It was the first organic compound to be artificially synthesized from inorganic starting materials, thus dispelling the concept of vitalism. Discovery It was the first organic compound to be artificially synthesized from inorganic starting materials, in 1828 by Friedrich Wöhler, who prepared it by the reaction of potassium cyanate with ammonium sulfate. Although Wöhler was attempting to prepare ammonium cyanate, by forming urea, he inadvertently discredited vitalism, the theory that the chemicals of living organisms are fundamentally different from inanimate matter, thus starting the discipline of organic chemistry. This discovery prompted Wöhler to write triumphantly to Berzelius: "I must tell you that I can make urea without the use of kidneys, either man or dog. Ammonium cyanate is urea." It is found in mammalian and amphibian urine as well as in some fish. Birds and reptiles excrete uric acid, comprising a different form of nitrogen metabolism that requires less water. [edit] Structure Urea is highly soluble in water and is therefore an efficient way for the human body to expel excess nitrogen. Due to extensive hydrogen bonding with water (up to six hydrogen bonds may form - two from the oxygen atom and one from each hydrogen), it is very soluble and thus is also a good fertilizer. The urea molecule is planar and retains its full molecular point symmetry, due to conjugation of one of each nitrogen's P orbital to the carbonyl double bond. Each carbonyl oxygen atom accepts four N-H-O hydrogen bonds,[citation needed] a very unusual feature for such a bond type. This dense (and energetically quite favourable) hydrogen bond network is probably established at the cost of efficient molecular packing: the structure is quite open, the ribbons forming tunnels with square cross-section. [edit] Physiology [edit] Endogenous production Main article: urea cycle The individual atoms that make up a urea molecule come from carbon dioxide, water, aspartate and ammonia in a metabolic pathway known as the urea cycle, an anabolic process. This expenditure of energy is necessary because ammonia, a common metabolic waste product, is toxic and must be neutralized. Urea production occurs in the liver and is under the regulatory control of N-acetylglutamate. In this cycle, amino groups donated by ammonia and L-aspartate are converted to urea, while L-ornithine, citrulline, L-argininosuccinate, and L-arginine act as intermediates. [edit] Function [edit] In humans Urea is essentially a waste product. However, it also plays a very important role in that it helps set up the countercurrent system in the nephrons. The countercurrent system in the nephrons allows for reabsorption of water and critical ions. Urea is reabsorbed in the inner medullary collecting ducts of the nephrons[2], thus raising the osmolarity in the medullary interstitium surrounding the thin ascending limb of the Loop of Henle. The greater the osmolarity of the medullary interstitium surrounding the thin ascending Loop of Henle, the more water will be resorbed out of the renal tubule back into the interstitium (and thus back into the body). Some of the urea from the medually interstitium that helped set up the Countercurrent System will also flow back into the tubule, through urea transporter 2, into the thin ascending limb of the loop of Henle, through the collecting ducts, and eventually out of the body as a component of urine. It is dissolved in blood (in a concentration of 2.5 - 7.5 mmol/liter) and excreted by the kidney as a component of urine. In addition, a small amount of urea is excreted (along with sodium chloride and water) in sweat. [edit] Regulation Main article: renal urea handling Control of urea by antidiuretic hormone allows the body to create hyperosmotic urine (urine that has more ions in it--is "more concentrated"--than that same person's blood plasma). Preventing the loss of water in this manner is important if the person's body needs to save water in order to maintain a suitable blood pressure or (more likely,) in order to maintain a suitable concentration of sodium ions in the blood plasma. [edit] Non-humans Most organisms have to deal with the excretion of nitrogen waste originating from protein and amino acid catabolism. In aquatic organisms the most common form of nitrogen waste is ammonia, while land-dwelling organisms convert the toxic ammonia to either urea or uric acid. Generally, birds and saurian reptiles excrete uric acid, while the remaining species, including mammals, excrete urea. Remarkably, tadpoles excrete ammonia, and shift to urea production during metamorphosis. In veterinary medicine, Dalmatian breeds of dogs are noteworthy in that they excrete nitrogen in the form of uric acid in the urine rather than in the urea form. This is due to a defect in one of the genes controlling expression of the conversion enzymes in the urea cycle. Despite the generalization above, the pathway has been documented not only in mammals and amphibians, but in many other organisms as well, including birds, invertebrates, insects, plants, yeast, fungi, and even microorganisms. [edit] Hazards Urea can be irritating to skin and eyes. Too high concentrations in the blood can cause damage to organs of the body. Low concentrations of urea such as in urine are not dangerous. It has been found that urea can cause algal blooms to produce toxins, and urea in runoff from fertilizers may play a role in the increase of toxic blooms.[3] Repeated or prolonged contact with urea in fertiliser form on the skin may cause dermatitis. The substance also irritates the eyes, the skin and the respiratory tract. The substance decomposes on heating above melting point producing toxic gases. Reacts violently with strong oxidants, nitrites, inorganic chlorides, chlorites and perchlorates causing fire and explosion hazard [edit] Synthetic production Urea is a nitrogen-containing chemical product which is produced on a scale of some 100,000,000 tons per year worldwide. Urea is commercially produced from synthetic ammonia and carbon dioxide. Urea can be produced as prills, granules, flakes, pellets, crystals and solutions. More than 90% of world production is destined for use as a fertilizer. Urea has the highest nitrogen content of all solid nitrogenous fertilizers in common use (46.4%) It therefore has the lowest transportation costs per unit of nitrogen nutrient. Urea is highly soluble in water and is therefore also very suitable for use in fertilizer solutions (in combination with ammonium nitrate: UAN), e.g. in 'foliar feed' fertilizers. Solid urea is marketed as prills or granules. The advantage of prills is that in general they can be produced more cheaply than granules which, because of their narrower particle size distribution have an advantage over prills if applied mechanically to the soil. Properties such as impact strength, crushing strength and free-flowing behaviour are particularly important in product handling, storage and bulk transportation. [edit] Commercial production Urea is commercially produced from two raw materials, ammonia and carbon dioxide. Large quantities of carbon dioxide are produced during the manufacture of ammonia from coal or from hydrocarbons such as natural gas and petroleum derived raw materials. This allows direct synthesis of urea from these raw materials. The production of urea from ammonia and carbon dioxide takes place in an equilibrium reaction, with incomplete conversion of the reactants. The various urea processes are characterized by the conditions under which urea formation takes place and the way in which unconverted reactants are further processed. Unconverted reactants can be used for the manufacture of other products, for example ammonium nitrate or sulfate, or they can be recycled for complete conversion to urea in a total-recycle process. Two principal reactions take place in the formation of urea from ammonia and carbon dioxide. The first reaction is exothermic: 2 NH3 + CO2 › H2N-COONH4 (ammonium carbamate) While the second reaction is endothermic: H2N-COONH4 › (NH2)2CO + H2O Both reactions combined are exothermic. The process, developed in 1922, is also called the Bosch-Meiser urea process after its discoverers. [edit] Uses [edit] Agricultural use Urea is used as a nitrogen release fertilizer as it hydrolyses back to ammonia and carbon dioxide, but its most common impurity, biuret, must be present at less than 2% as it impairs plant growth. It is also used in many multi-component solid fertilizer formulations. Its action of nitrogen release is due to the conditions favouring the reagent side of the equilibriums which produce urea. Urea is usually spread at rates of between 40 and 300 kg/ha, but actual spreading rates will vary according to farm type and region. It is better to make several small to medium applications at intervals to minimise leaching losses and increase efficient use of the N applied compared with single heavy applications. During summer, urea should be spread just before, or during rain to reduce possible losses from volatilisation (process where nitrogen is lost to the atmosphere as ammonia gas). Urea should not be mixed for any length of time with other fertilizers as problems of physical quality may result. Because of the high nitrogen concentration in urea, it is very important to achieve an even spread. Make sure that the application equipment has been correctly calibrated and is properly used. Do not drill on contact with or close to seed, due to the risk of germination damage. Urea dissolves in water for application as a spray or through irrigation systems. In grain and cotton crops, urea is often applied at the time of the last cultivation before planting. It should be applied into, or be incorporated into the soil. In high rainfall areas and on sandy soils (where nitrogen can be lost through leaching) and where good in-season rainfall is expected, urea can be side or top-dressed during the growing season. Top-dressing is also popular on pasture and forage crops. In sugarcane, urea is side-dressed after planting, and applied to each ratoon crop (see ratooning). In irrigated crops, urea can be applied dry to the soil, or dissolved and applied through the irrigation water. Urea will dissolve in its own weight in water, but it becomes increasingly difficult to dissolve as the concentration increases. Dissolving urea in water is endothermic, causing the temperature of the solution to fall when urea dissolves. As a practical guide, when preparing urea solutions for fertigation (injection into irrigation lines), dissolve no more than 30 kg urea per 100 L water. In foliar sprays, urea concentrations of 0.5 – 2.0% are often used in horticultural crops. As urea sprays may damage crop foliage, specific advice should be sought before use. Low biuret grades of urea should be used if urea sprays are to be applied regularly or to sensitive horticultural crops. [edit] Storage of urea fertilizer Like most nitrogen products, urea absorbs moisture from the atmosphere. Therefore it should be stored either in closed/sealed bags on pallets, or if stored in bulk, covered with a tarpaulin. As with most solid fertilizers, it should also be stored in a cool, dry, well ventilated area. [edit] Industrial use Urea has the ability to form 'loose compounds' with many organic compounds. The organic compounds are held in channels formed by interpenetrating helices comprising of hydrogen bonded urea molecules. This behaviour can be used to separate mixtures and has been used in the production of aviation fuel and lubricating oils. As the helices are interconnected all helices in a crystal must have the same 'handedness'. This is determined when the crystal is nucleated and can thus be forced by seeding. This property has been used to separate racemic mixtures. [edit] Further commercial uses include: Urea is also employed as a stabilizer in nitrocellulose explosives As a reactant in the NOx-reducing SNCR and SCR reactions in exhaust gases from combustion, for example from power plants and diesel engines. As a component of fertilizer and animal feed, providing a relatively cheap source of nitrogen to promote growth. As a raw material for the manufacture of plastics specifically, urea-formaldehyde resin. As a raw material for the manufacture of various glues (urea-formaldehyde or urea-melamine-formaldehyde). The latter is waterproof and is used for marine plywood. As an alternative to rock salt in the deicing of roadways and runways. It does not promote metal corrosion to the extent that salt does. As an additive ingredient in cigarettes, designed to enhance flavour. Sometimes used as a browning agent in factory-produced pretzels. As an ingredient in some hair conditioners, facial cleansers, bath oils and lotions. It is also used as a reactant in some ready-to-use cold compresses for first-aid use, due to the endothermic reaction it creates when mixed with water. Used, along with salts, as a cloud seeding agent to expedite the condensation of water in clouds, producing precipitation. The ability of urea to form clathrates (also called host-guest complexes, inclusion compounds, and adducts) was used in the past to separate paraffins. As a flame-proofing agent (commonly used in dry chemical fire extinguishers as Urea-potassium bicarbonate) As an ingredient in many tooth whitening products. Added to stainless steel alloys used in some Japanese knives to retain sharpness. As a cream to soften the skin, especially cracked skin on the bottom of one's feet. As an ingredient in dish soap. [edit] Laboratory use Urea is a powerful protein denaturant. This property can be exploited to increase the solubility of some proteins. For this application it is used in concentrations up to 10 M. Urea is used to effectively disrupt the noncovalent bonds in proteins. Urea is an ingredient in the synthesis of urea nitrate. Urea nitrate is also a high explosive very similar to ammonium nitrate, however it may even be more powerful because of its complexity. VOD is 11,000 fps to 15,420 fps. [edit] Medical use Drug use Urea is used in topical dermatological products to promote rehydration of the skin. If covered by an occlusive dressing, 40% urea preparations may also be used for nonsurgical debridement of nails. This drug is also used as an earwax removal aid. Clinical diagnosis Main article: blood urea nitrogen The blood urea nitrogen (BUN) test is a measure of the amount of nitrogen in the blood that comes from urea. It is used as a marker of renal function. Other diagnostic use Isotopically-labeled urea (carbon-14 - radioactive, or carbon-13 - stable isotope) is used in the urea breath test, which is used to detect the presence of the bacteria Helicobacter pylori (H. pylori) in the stomach and duodenum of humans. The test detects the characteristic enzyme urease, produced by H. pylori, by a reaction that produces ammonia from urea. This increases the pH (reduces acidity) of the stomach environment around the bacteria. Similar bacteria species to H. pylori can be identified by the same test in animals such as apes, dogs, and cats (including big cats). [edit] Textile use Urea in textile laboratories are frequently used both in dyeing and printing as an important auxiliary which provides solubility to the bath and retains some moisture which is required for the dyeing or printing process. [edit] Ionic liquid Choline chloride, in mixture with urea, is used as a deep eutectic solvent, a type of ionic liquid. [edit] Ureas The term urea or carbamide is also used for the class of chemical compounds sharing the same functional group RR'N-CO-NRR' based on a carbonyl group flanked by two organic amine residues. They can be accessed in the laboratory by reaction of phosgene with primary or secondary amines. Example of ureas are the compounds carbamide peroxide, allantoin and Hydantoin. Ureas are closely related to biurets and structurally related to amides, carbamates, diimides, carbodiimides and thiocarbamides. [edit] Reactions Urea reacts with alcohols to form urethanes. Urea reacts with malonic esters to make barbituric acids.